Pregnancy & Medication Safety

What Allergy Medication is Safe During Pregnancy?

Faith Coleman

Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 22nd, 2026.

Loratadine (Claritin) and cetirizine (Zyrtec) are considered the safest allergy medications during pregnancy. These second-generation antihistamines are classified as Category B by the FDA, meaning animal studies show no risk, and they're generally recommended as first-line treatments. Chlorpheniramine and diphenhydramine (Benedryl), both first-generation antihistamines, are also considered safe but may cause drowsiness. Nasal saline rinses and intranasal corticosteroids like budesonide are additional safe options. Studies involving over 200,000 pregnant women found no increased risk of birth defects with these medications. Always consult your healthcare provider before starting any medication during pregnancy, as individual circumstances may vary and proper dosing is essential.

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