How Long Does Zepbound Stay in Your System
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Zepbound (tirzepatide) stays in your system for approximately 5 weeks after your last injection. The medication has a half-life of about 5 days, meaning it takes roughly 5 half-lives (25 days) for the drug to be mostly eliminated from your body. However, trace amounts may be detectable for up to 7 weeks. Zepbound's extended presence in your system is due to its weekly dosing schedule and slow metabolism. The drug binds to proteins in your blood, which prolongs its activity. If you're discontinuing Zepbound, you may continue experiencing appetite suppression and blood sugar effects for several weeks after your final dose.
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