How Does Zepbound Work
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Zepbound works by mimicking two hormones, GLP-1 and GIP, that naturally regulate blood sugar and appetite. These hormones slow gastric emptying, making you feel full longer after eating, while also signaling the brain to reduce hunger. The medication contains tirzepatide, which activates receptors in the pancreas to increase insulin production when blood sugar rises. Clinical trials showed participants lost an average of 15-20% of their body weight over 72 weeks. Zepbound is administered as a weekly subcutaneous injection, starting at 2.5 mg and potentially increasing to 15 mg based on tolerance and effectiveness.
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