GLP 1 & Weight Loss

How Does Ozempic Work

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.

Ozempic contains semaglutide, a GLP-1 receptor agonist that mimics a natural hormone in your intestines. This medication slows gastric emptying, keeping food in your stomach longer to increase satiety. It also signals your brain to reduce appetite and affects insulin production to lower blood sugar levels. Clinical trials show patients typically lose 12-14% of their body weight within 68 weeks. The medication requires weekly injections and works best when combined with diet and exercise changes.

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