Does Zepbound Need to Be Refrigerated
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Yes, Zepbound must be refrigerated at temperatures between 36°F and 46°F (2°C to 8°C). The medication should be stored in its original carton to protect it from light and never frozen. If accidentally frozen, Zepbound becomes unsafe to use and must be discarded. You can remove Zepbound from the refrigerator up to 21 days before injection, but it must be kept at room temperature below 86°F (30°C) during this time. Always check the expiration date and inspect the solution before use—it should be clear and colorless without particles or discoloration.
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