Does Zepbound Help with PCOS Weight Gain?

Zepbound may help some people with PCOS lose weight by reducing appetite, but it is not specifically approved to treat PCOS, and evidence in people with PCOS is still limited. PCOS commonly affects people of reproductive age and is often associated with insulin resistance and difficulty managing weight. Patients who could become pregnant should also discuss contraception and pregnancy plans with their clinician because tirzepatide should not be used during pregnancy and can temporarily reduce the effectiveness of oral hormonal contraceptives after treatment begins and after dose increases. Zepbound contains tirzepatide, which improves insulin sensitivity and helps regulate blood sugar levels while suppressing appetite. In a major 72-week trial of adults with obesity or overweight without diabetes, average weight loss varied by dose and was about 15% to 21%; individual results vary. For some people with PCOS, weight loss may improve insulin resistance and menstrual regularity. It is less clear whether Zepbound directly improves other PCOS symptoms, such as excess hair growth.