Does Zepbound Cause Hair Loss
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Hair loss is a potential but uncommon side effect of Zepbound (tirzepatide). Clinical trials show that less than 3% of patients experienced hair loss or alopecia while taking this GLP-1 receptor agonist. The mechanism isn't fully understood, but rapid weight loss itself can trigger temporary hair thinning called telogen effluvium. Most hair loss associated with weight loss medications is reversible once your body adjusts to the treatment or after discontinuation. If you notice significant hair thinning while taking Zepbound, discuss this with your healthcare provider to determine if it's medication-related or due to other factors like nutritional deficiencies or stress.
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