Does Tirzepatide Cause Acid Reflux?

Yes, tirzepatide commonly causes acid reflux and other gastrointestinal side effects. Clinical trials show that up to 25% of patients experience GERD symptoms, including heartburn, regurgitation, and stomach discomfort. This occurs because tirzepatide slows gastric emptying, causing food to remain in the stomach longer and potentially triggering reflux. The side effect is typically dose-dependent and most pronounced during the initial weeks of treatment or dose increases. Most patients find symptoms improve as their body adjusts to the medication, usually within 4-8 weeks. If you're experiencing persistent acid reflux on tirzepatide, we can help you explore management strategies and determine if dosage adjustments might be appropriate for your situation.