GLP 1 & Weight Loss

Does Ozempic Make You Tired

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.

Yes, Ozempic can cause fatigue as a side effect, though it's not among the most common reactions. Our experience shows that tiredness typically occurs during the first few weeks as your body adjusts to the medication. Clinical studies report fatigue in approximately 5-8% of patients taking semaglutide. The tiredness often stems from blood sugar changes, reduced caloric intake due to appetite suppression, or initial digestive adjustments. Most patients find their energy levels stabilize after 4-6 weeks of consistent use. If persistent fatigue interferes with daily activities, we recommend discussing dosage adjustments or timing changes with your healthcare provider to optimize your treatment experience.

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