GLP 1 & Weight Loss

Does Ozempic Cause Diarrhea

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.

Yes, Ozempic can cause diarrhea as a common gastrointestinal side effect. Clinical trials show that 8-9% of patients experience diarrhea when taking Ozempic, making it one of the more frequent adverse reactions alongside nausea and vomiting. This occurs because Ozempic slows gastric emptying and affects gut motility as part of how GLP-1 receptor agonists work. The diarrhea typically develops within the first few weeks of treatment and often improves as your body adjusts to the medication. Most cases are mild to moderate, but some patients may need dosage adjustments or additional management strategies. If you're experiencing persistent or severe diarrhea while taking Ozempic, we can help you understand when to contact your healthcare provider and discuss potential solutions.

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