Pregnancy & Medication Safety

Can You Take Unisom While Pregnant for Sleep?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 22nd, 2026.

Unisom Sleep Tabs (doxylamine) is generally considered safe during pregnancy and is FDA Pregnancy Category A. The American College of Obstetricians and Gynecologists recognizes doxylamine as a first-line treatment for pregnancy-related nausea and sleep issues. However, Unisom SleepGels contain diphenhydramine, which is Category B and requires more caution. Studies show doxylamine has been used safely by millions of pregnant women since the 1950s. The typical dose is 25mg at bedtime, but you should always consult your healthcare provider before starting any sleep medication during pregnancy. They can recommend the safest formulation and appropriate dosing based on your specific trimester and health history.

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