Pregnancy & Medication Safety

Can You Take Ibuprofen While Pregnant?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.

No, ibuprofen should be avoided during pregnancy, especially after 20 weeks. The FDA strongly advises against NSAIDs like ibuprofen during the second and third trimesters due to serious risks including kidney problems, reduced amniotic fluid, and potential heart defects in the baby. Taking ibuprofen after 30 weeks can cause premature closure of the ductus arteriosus, a critical fetal blood vessel. Studies show that regular use increases miscarriage risk by up to 80%. While occasional first-trimester use may be less risky, safer alternatives like acetaminophen (Tylenol) are recommended throughout pregnancy for pain and fever relief.

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