Can You Take Allergy Medicine While on Ozempic?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
Most allergy medications are safe to take with Ozempic. No direct drug interactions exist between semaglutide (Ozempic) and common antihistamines like Claritin, Zyrtec, or Benadryl. However, allergy medications containing decongestants may affect blood sugar levels, which is particularly important for people with diabetes using Ozempic. Nasal steroid sprays like Flonase are generally safe with GLP-1 medications. Take Ozempic as prescribed and space other medications at least 30 minutes apart to avoid potential absorption issues. Consult your healthcare provider to review your specific allergy medications for compatibility with your Ozempic treatment plan.
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