Can You Drink Coffee While Taking Semaglutide?

Yes, you can generally drink coffee while taking semaglutide, but timing and moderation matter. Coffee itself doesn't interfere with semaglutide's effectiveness, but caffeine can worsen common side effects like nausea, stomach upset, and jitteriness that affect up to 20% of users. The medication slows gastric emptying, which means coffee may stay in your stomach longer and potentially increase discomfort. For best results, drink coffee between meals rather than with food, start with smaller amounts to gauge your tolerance, and consider switching to decaf if you experience increased nausea.