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Zetia (ezetimibe) is a cholesterol absorption inhibitor. It works in the small intestine to block a protein called NPC1L1 that transports dietary and biliary cholesterol into the bloodstream. This reduces the amount of cholesterol reaching the liver and lowers LDL levels in the blood.

Yes. Zetia is commonly prescribed alongside a statin such as atorvastatin or rosuvastatin. Because the two drug classes lower LDL through different mechanisms, combining them typically produces greater LDL reductions than either drug alone.

As monotherapy, ezetimibe typically reduces LDL cholesterol by about 18 to 25 percent. When added to a statin, it can provide an additional 20 to 25 percent reduction on top of what the statin achieves.

Zetia is generally well tolerated. The most commonly reported side effects include upper respiratory infections, diarrhea, joint pain, and fatigue. Liver enzyme elevations are rare. Muscle-related side effects are uncommon when ezetimibe is used without a statin.

Zetia is not recommended during pregnancy or breastfeeding. Patients with active liver disease should not take ezetimibe. If you are already on a statin, your physician will also review liver function before prescribing the combination.

Ezetimibe begins lowering LDL within about two weeks of starting treatment. A full assessment of its effect on your lipid panel is typically done after four to twelve weeks, using a fasting cholesterol blood test.

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