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Xofluza (baloxavir marboxil) is a prescription antiviral that targets the cap-dependent endonuclease enzyme influenza viruses need to copy their genetic material. By blocking this enzyme, Xofluza stops the virus from replicating inside the body. It is taken as a single oral dose and works through a different mechanism than older antivirals like oseltamivir.

Xofluza works best when taken within 48 hours of the first appearance of flu symptoms. Starting treatment early in the course of illness gives the medication the best chance to reduce how long and how severely you feel sick. If more than 48 hours have passed since symptoms began, talk to your physician about whether treatment is still appropriate for you.

Xofluza is FDA-approved for the treatment of acute uncomplicated influenza in people 12 years and older who have been symptomatic for no more than 48 hours. It is also approved for post-exposure prevention of influenza in people 12 and older. Patients with complicated or severe flu, or those who are hospitalized, typically need a different treatment approach.

Xofluza is taken as a single oral dose. The dose is weight-based: patients weighing 40 to less than 80 kg take 40 mg, and patients weighing 80 kg or more take 80 mg. Because it is a one-time dose, there is no multi-day course to remember, which can make it easier to complete treatment.

The most commonly reported side effects of Xofluza in clinical trials included diarrhea, bronchitis, nausea, nasopharyngitis, and headache. Most side effects were mild to moderate. Contact your physician if you experience severe or unexpected symptoms after taking the medication.

Some products can reduce the effectiveness of Xofluza. Antacids or supplements containing polyvalent cations such as calcium, iron, magnesium, or zinc can bind to baloxavir and lower its absorption. You should avoid taking these products within a few hours of your Xofluza dose. Always tell your prescribing physician about all medications and supplements you are taking.

Yes. Xofluza is a treatment medication taken after you already have flu symptoms. The flu vaccine is given before the flu season to help prevent infection in the first place. Getting vaccinated annually is still recommended even for people who have been treated for influenza, as the vaccine helps protect against future infection.

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