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Phexxi maintains the natural acidic pH of the vagina, which reduces sperm motility. By keeping pH low, it creates an environment that limits sperm from swimming effectively to reach an egg. It does not use hormones and does not work as an emergency contraceptive.

Phexxi should be applied vaginally no more than one hour before each act of intercourse. If more than one hour passes before sex, you need to apply a new dose. A separate dose is required for each additional act of intercourse.

In clinical trials, Phexxi had an efficacy of approximately 86 percent with typical use over seven menstrual cycles, meaning about 14 out of 100 users may become pregnant over that period. For higher effectiveness, it can be combined with barrier methods such as condoms, though it should not be used with a diaphragm or vaginal ring.

No. Phexxi does not protect against sexually transmitted infections (STIs), including HIV. For STI protection, condoms should be used alongside Phexxi.

The most commonly reported side effects include vulvovaginal burning, itching, and discomfort. Some users also experience vaginal discharge, genital discomfort in the partner, yeast infections, bacterial vaginosis, and urinary tract infections. If you have a history of recurrent UTIs, discuss this with your provider before starting Phexxi.

Phexxi can be used alongside condoms or hormonal contraceptives for added effectiveness. However, it should not be used at the same time as a vaginal ring or diaphragm, as it may interfere with these devices.

Phexxi may not be appropriate for people with a history of recurrent urinary tract infections or urinary tract abnormalities, as it has been associated with an increased risk of UTIs. Your Doctronic physician will review your health history to determine whether Phexxi is right for you.

Doctronic uses an AI-powered evaluation to gather your health history and symptoms, which is then reviewed by a licensed physician. The physician determines whether a treatment plan, including a prescription if appropriate, is right for you. The entire process is secure, HIPAA-compliant, and available to adults 18 and older in any U.S. state.