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Isordil is the brand name for isosorbide dinitrate, a long-acting organic nitrate. It is used to prevent and treat chest pain (angina pectoris) in people with coronary artery disease by relaxing blood vessels and reducing the workload on the heart.

Isordil is typically taken by mouth two to three times daily as directed by your physician. To reduce the risk of nitrate tolerance, doses are usually scheduled with an 8- to 12-hour nitrate-free interval. Your doctor will set the specific dose and schedule based on your individual needs.

Nitrate tolerance occurs when the body becomes less responsive to the drug after continuous exposure, reducing its effectiveness. It is avoided by following a dosing schedule that includes a daily nitrate-free period, typically overnight, as your physician prescribes.

Isordil is often used alongside other cardiac medications such as beta-blockers or calcium channel blockers. However, it must not be combined with phosphodiesterase-5 inhibitors (such as sildenafil, tadalafil, or vardenafil) because the combination can cause a severe and potentially life-threatening drop in blood pressure. Always share your full medication list with your physician.

The most common side effects include headache, dizziness, lightheadedness, and flushing, particularly when starting treatment or after a dose increase. These often improve as your body adjusts. Contact your care team if you experience a sudden severe drop in blood pressure, fainting, or worsening chest pain.

Isordil and nitroglycerin are both organic nitrates that work through a similar mechanism, but they are different medications. Nitroglycerin is typically used for rapid relief of an acute angina attack, while Isordil is taken regularly for prevention. Isordil is not appropriate as a first-line rescue treatment for an acute attack.

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