Antibiotics for Cellulitis: Which One Is Right for You?
Published: Nov 08, 2023
Choosing the right antibiotic for cellulitis can be tricky. It depends on factors like severity of infection, risk for MRSA, and your overall health status.
Contents
First-Line Treatments
For most mild to moderate cases of cellulitis, doctors typically prescribe oral antibiotics that target common skin bacteria. These include dicloxacillin, cephalexin, or amoxicillin-clavulanate. Think of these as the 'general-purpose' antibiotics for skin infections.
When MRSA is a Concern
If there's a risk of methicillin-resistant Staphylococcus aureus (MRSA), your doctor might choose different antibiotics. Trimethoprim-sulfamethoxazole, doxycycline, or linezolid are common choices. These are like specialized tools designed to tackle tougher bacteria.

Severe Cases and IV Antibiotics
For severe cellulitis or in patients with weakened immune systems, intravenous (IV) antibiotics may be necessary. Vancomycin is often the go-to IV antibiotic for serious skin infections. It's like bringing out the big guns when the infection is more serious.
Frequently Asked Questions
Usually 5-14 days, depending on the severity.
No, always complete the full course as prescribed.
Yes, common ones include nausea and diarrhea.
Key Takeaways
The right antibiotic can make all the difference in treating cellulitis effectively and preventing complications.
References
- Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis 2014; 59:147.
- Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011; 52:e18.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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