Repatha vs. Livalo
See how Repatha and Livalo compare on approved uses, dosing, side effects, and cost.
Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on September 8th, 2026.
Key Takeaways
Repatha is an injectable PCSK9 inhibitor given every two weeks or monthly, while Livalo is a daily oral statin, so the two lower cholesterol through very different mechanisms and routines.
Repatha has cardiovascular outcomes evidence and an FDA-approved indication for reducing major cardiovascular events. Livalo is not FDA-approved specifically to prevent cardiovascular events, although pitavastatin has been studied in a cardiovascular outcomes trial and statins are commonly used for prevention when appropriate.
Both drugs lower LDL cholesterol but have different safety considerations. Livalo can cause muscle symptoms and, rarely, serious muscle injury or liver problems. Repatha can cause injection-site reactions and cold- or flu-like symptoms; serious allergic reactions are possible. Actual cost depends on insurance coverage, discounts, and whether a generic is used.
Repatha vs. Livalo Drug Summary
Repatha
Repatha (evolocumab) is a PCSK9 inhibitor given as a subcutaneous injection to lower LDL cholesterol and reduce cardiovascular risk in adults with heart disease or genetic high cholesterol. It's injected every two weeks or once a month, depending on the dose prescribed.
Livalo
Livalo (pitavastatin) is a statin that lowers LDL cholesterol as an add-on to diet in adults with high cholesterol or genetic high cholesterol. It's taken as a once-daily tablet, with doses ranging from 1 mg to 4 mg.
Repatha vs. Livalo Side Effects
Repatha
Livalo
Repatha vs. Livalo Dosage
Repatha
Livalo
| STAGE | DOSE | WHEN |
| Starting dose | 140 mg every 2 weeks | At the start |
| Maximum dose | 420 mg every 2 weeks | If needed |
| Dose changes | 2 increases | As tolerated |
| STAGE | DOSE | WHEN |
| Starting dose | 1 mg once daily | At the start |
| Maximum dose | 4 mg once daily | If needed |
| Dose changes | 2 increases | As tolerated |
Repatha
| STAGE | DOSE | WHEN |
| Starting dose | 140 mg every 2 weeks | At the start |
| Maximum dose | 420 mg every 2 weeks | If needed |
| Dose changes | 2 increases | As tolerated |
Livalo
| STAGE | DOSE | WHEN |
| Starting dose | 1 mg once daily | At the start |
| Maximum dose | 4 mg once daily | If needed |
| Dose changes | 2 increases | As tolerated |
Repatha vs. Livalo Indications
Repatha
Repatha is FDA-approved to reduce the risk of heart attack, stroke, and certain heart procedures in adults with established cardiovascular disease. It's also approved to lower LDL cholesterol in people with heterozygous or homozygous familial hypercholesterolemia, including children as young as 10.
Reduce risk of heart attack and stroke in adults with heart disease
Lower LDL in heterozygous familial hypercholesterolemia (add-on)
Lower LDL in homozygous familial hypercholesterolemia (add-on)
Approved for children 10 and older with familial hypercholesterolemia
Livalo
Livalo is FDA-approved as an add-on to diet to lower LDL cholesterol, total cholesterol, and triglycerides in adults with primary hyperlipidemia or mixed dyslipidemia. It's also approved for heterozygous familial hypercholesterolemia, including children 8 and older, and is sometimes used off-label for primary prevention of atherosclerotic heart disease.
Lower LDL and triglycerides in adults with high cholesterol
Lower LDL in heterozygous familial hypercholesterolemia
Approved for children 8 and older with familial hypercholesterolemia
Off-label: primary prevention of atherosclerotic heart disease
Repatha vs. Livalo Pros and Cons
Repatha
Repatha offers strong, trial-proven cardiovascular protection delivered through an antibody injection rather than a daily pill. It costs more than most oral statins and has no biosimilar yet, so insurance coverage and prior authorization often shape access.
Pros
Injected every two weeks or once monthly, no daily pill needed
Outcomes trial (FOURIER) showed fewer heart attacks and strokes
Approved for pediatric familial hypercholesterolemia starting age 10
No liver-related contraindications like active liver disease
Cons
Requires injection, which some patients find less convenient
Roughly $580 to $730 per month before insurance, more than Livalo
No biosimilar competition yet, keeping the price elevated
Can cause injection site reactions
Livalo
Livalo works like other statins to lower LDL cholesterol through a once-daily tablet with a long safety track record. It costs less than Repatha but carries the typical statin risks of muscle pain and, rarely, liver problems.
Pros
Oral tablet taken once daily, no injections involved
Roughly $315 to $410 per month before insurance, less than Repatha
Minimal CYP3A4 metabolism means fewer drug interactions than many statins
Long-standing safety record since its 2009 approval
Cons
Carries risk of myopathy and rare rhabdomyolysis, needing monitoring
Contraindicated with cyclosporine and dose-limited with some antibiotics
Not approved for children under age 8
No dedicated cardiovascular outcomes trial of its own
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