Latuda vs. Invega

See how Latuda and Invega compare on approved uses, dosing, side effects, and cost.

Key Takeaways

  • Latuda is FDA-approved for schizophrenia and bipolar depression, while Invega covers schizophrenia and schizoaffective disorder but not bipolar depression.

  • Latuda must be taken with at least 350 calories of food for the body to absorb it properly, while Invega can be taken with or without food.

  • Invega also comes as a long-acting injection given monthly, every three months, or every six months, an option Latuda does not offer.

Latuda vs. Invega Drug Summary

Latuda

Latuda (lurasidone) is an atypical antipsychotic used to treat schizophrenia in adults and teens 13 and older, and depressive episodes tied to bipolar I disorder in adults and children 10 and older. It is a once-daily tablet that must be taken with at least 350 calories of food so the body can absorb it.

Invega

Invega (paliperidone) is an atypical antipsychotic used to treat schizophrenia in adults and teens 12 and older, and schizoaffective disorder in adults, alone or alongside mood stabilizers or antidepressants. It is a once-daily extended-release tablet that can be swallowed with or without food.

Latuda vs. Invega Side Effects

Latuda

Most common
extrapyramidal symptoms (up to 14%)
akathisia (up to 13%)
somnolence (up to 17%)
nausea (up to 10%)

Invega

Most common
extrapyramidal symptoms (up to 13%)
akathisia (up to 12%)
insomnia (up to 15%)
headache (up to 10%)

Latuda vs. Invega Dosage

Latuda

Dosage
Dosage Table
STAGE DOSE WHEN
Starting dose 40 mg once daily Day 1
Maximum dose 20-80 mg/day If needed
Dose changes 2 increases As tolerated

Invega

Dosage
Dosage Table
STAGE DOSE WHEN
Starting dose 3 mg once daily At the start
Maximum dose 12 mg once daily If needed
Dose changes 3 increases As tolerated

Latuda vs. Invega Indications

Latuda

Latuda is FDA-approved for schizophrenia in adults and adolescents 13 to 17, and for depressive episodes linked to bipolar I disorder. For bipolar depression it can be used alone or added to lithium or valproate. It is not approved for bipolar mania.

  • Schizophrenia (adults and teens 13-17)

  • Bipolar I depression, monotherapy (adults and ages 10-17)

  • Bipolar I depression, add-on to lithium or valproate (adults)

Invega

Invega is FDA-approved for schizophrenia in adults and adolescents 12 to 17, and for schizoaffective disorder in adults. For schizoaffective disorder it can be used alone or alongside mood stabilizers or antidepressants. It is not approved for dementia-related psychosis.

  • Schizophrenia (adults and teens 12-17)

  • Schizoaffective disorder, monotherapy (adults)

  • Schizoaffective disorder, add-on to mood stabilizers or antidepressants

Latuda vs. Invega Pros and Cons

Latuda

Latuda covers both schizophrenia and bipolar depression, and starts at an effective dose without a titration period. It must be taken with a substantial meal to absorb properly, and it is not available as a long-acting injection.

Pros

  • FDA-approved for bipolar depression, not just schizophrenia

  • Starts at an effective dose with no titration schedule needed

  • Available in five tablet strengths for flexible dosing

Cons

  • Must be taken with a substantial meal (350+ calories) to absorb properly

  • Only available as a daily oral tablet, no long-acting injectable option

  • Dose must be cut in half when combined with moderate CYP3A4 inhibitors

Invega

Invega treats schizophrenia and schizoaffective disorder, and offers long-acting injectable options for people who have trouble sticking to a daily pill. It carries a distinct warning about QT prolongation and is not approved for bipolar depression.

Pros

  • Also available as long-acting injections dosed monthly, every 3 months, or every 6 months

  • Can be taken with or without food

  • Approved for schizoaffective disorder in addition to schizophrenia

Cons

  • Carries a specific warning to avoid other QT-prolonging drugs

  • Not approved for bipolar depression

  • Dose needs adjustment for reduced kidney function

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