Latuda vs. Invega
See how Latuda and Invega compare on approved uses, dosing, side effects, and cost.
Key Takeaways
Latuda is FDA-approved for schizophrenia and bipolar depression, while Invega covers schizophrenia and schizoaffective disorder but not bipolar depression.
Latuda must be taken with at least 350 calories of food for the body to absorb it properly, while Invega can be taken with or without food.
Invega also comes as a long-acting injection given monthly, every three months, or every six months, an option Latuda does not offer.
Latuda vs. Invega Drug Summary
Latuda
Latuda (lurasidone) is an atypical antipsychotic used to treat schizophrenia in adults and teens 13 and older, and depressive episodes tied to bipolar I disorder in adults and children 10 and older. It is a once-daily tablet that must be taken with at least 350 calories of food so the body can absorb it.
Invega
Invega (paliperidone) is an atypical antipsychotic used to treat schizophrenia in adults and teens 12 and older, and schizoaffective disorder in adults, alone or alongside mood stabilizers or antidepressants. It is a once-daily extended-release tablet that can be swallowed with or without food.
Latuda vs. Invega Side Effects
Latuda
Invega
Latuda vs. Invega Dosage
Latuda
Invega
| STAGE | DOSE | WHEN |
| Starting dose | 40 mg once daily | Day 1 |
| Maximum dose | 20-80 mg/day | If needed |
| Dose changes | 2 increases | As tolerated |
| STAGE | DOSE | WHEN |
| Starting dose | 3 mg once daily | At the start |
| Maximum dose | 12 mg once daily | If needed |
| Dose changes | 3 increases | As tolerated |
Latuda
| STAGE | DOSE | WHEN |
| Starting dose | 40 mg once daily | Day 1 |
| Maximum dose | 20-80 mg/day | If needed |
| Dose changes | 2 increases | As tolerated |
Invega
| STAGE | DOSE | WHEN |
| Starting dose | 3 mg once daily | At the start |
| Maximum dose | 12 mg once daily | If needed |
| Dose changes | 3 increases | As tolerated |
Latuda vs. Invega Indications
Latuda
Latuda is FDA-approved for schizophrenia in adults and adolescents 13 to 17, and for depressive episodes linked to bipolar I disorder. For bipolar depression it can be used alone or added to lithium or valproate. It is not approved for bipolar mania.
Schizophrenia (adults and teens 13-17)
Bipolar I depression, monotherapy (adults and ages 10-17)
Bipolar I depression, add-on to lithium or valproate (adults)
Invega
Invega is FDA-approved for schizophrenia in adults and adolescents 12 to 17, and for schizoaffective disorder in adults. For schizoaffective disorder it can be used alone or alongside mood stabilizers or antidepressants. It is not approved for dementia-related psychosis.
Schizophrenia (adults and teens 12-17)
Schizoaffective disorder, monotherapy (adults)
Schizoaffective disorder, add-on to mood stabilizers or antidepressants
Latuda vs. Invega Pros and Cons
Latuda
Latuda covers both schizophrenia and bipolar depression, and starts at an effective dose without a titration period. It must be taken with a substantial meal to absorb properly, and it is not available as a long-acting injection.
Pros
FDA-approved for bipolar depression, not just schizophrenia
Starts at an effective dose with no titration schedule needed
Available in five tablet strengths for flexible dosing
Cons
Must be taken with a substantial meal (350+ calories) to absorb properly
Only available as a daily oral tablet, no long-acting injectable option
Dose must be cut in half when combined with moderate CYP3A4 inhibitors
Invega
Invega treats schizophrenia and schizoaffective disorder, and offers long-acting injectable options for people who have trouble sticking to a daily pill. It carries a distinct warning about QT prolongation and is not approved for bipolar depression.
Pros
Also available as long-acting injections dosed monthly, every 3 months, or every 6 months
Can be taken with or without food
Approved for schizoaffective disorder in addition to schizophrenia
Cons
Carries a specific warning to avoid other QT-prolonging drugs
Not approved for bipolar depression
Dose needs adjustment for reduced kidney function
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