Aviane vs. Kyleena

See how Aviane and Kyleena compare on approved uses, dosing, side effects, and cost.

Key Takeaways

  • Aviane is a daily pill that needs to be taken at the same time every day, while Kyleena is placed once and works for up to 5 years.

  • Aviane carries a boxed warning about cardiovascular risk in smokers over 35, a concern that does not apply to Kyleena's local hormone delivery.

  • Kyleena's most common effects include vulvovaginitis and ovarian cysts, while Aviane's most common effects include headache, abdominal pain, and nausea.

Aviane vs. Kyleena Drug Summary

Aviane

Aviane is a combined oral contraceptive containing levonorgestrel and ethinyl estradiol, used to prevent pregnancy. It is taken as a once-daily tablet in a 28-day pack, with 21 active pills followed by 7 inactive ones.

Kyleena

Kyleena is a levonorgestrel-releasing intrauterine device, a progestin-only contraceptive placed inside the uterus. It is inserted once by a clinician and prevents pregnancy for up to 5 years.

Aviane vs. Kyleena Side Effects

Aviane

Most common
Headache (rate not specified)
Abdominal pain (rate not specified)
Nausea (rate not specified)
Acne (rate not specified)

Kyleena

Most common
Vulvovaginitis (up to 24%)
Ovarian cysts (up to 22%)
Abdominal/pelvic pain (up to 21%)
Headache/migraine (up to 15%)

Aviane vs. Kyleena Dosage

Aviane

Dosage
Dosage Table
STAGE DOSE WHEN
Starting dose 1 orange tablet daily Days 1-21
Maximum dose 1 inert tablet daily Days 22-28
Dose changes 1 increase Every 21 days

Kyleena

Dosage
Dosage Table
STAGE DOSE WHEN
Starting dose 19.5 mg IUS, one device At the start
Maximum dose 19.5 mg IUS, one device Same as starting
Dose changes None Fixed dose

Aviane vs. Kyleena Indications

Aviane

Aviane is approved to prevent pregnancy in females of reproductive potential. It has not been well studied in people with a BMI over 35, so it is not recommended for that group.

  • Prevents pregnancy with a daily oral tablet

  • Helps regulate menstrual cycle timing

  • Can be started or stopped without a procedure

  • Requires consistent daily use for full effectiveness

Kyleena

Kyleena is approved to prevent pregnancy for up to 5 years after a single insertion. It is not approved for emergency contraception or for use before a person's first period.

  • Prevents pregnancy for up to 5 years

  • Requires only one insertion procedure

  • Works mainly through local, not systemic, hormones

  • Can be removed early if pregnancy is desired sooner

Aviane vs. Kyleena Pros and Cons

Aviane

Aviane offers a familiar, well-established dosing routine that a person controls day to day without a procedure. It is not the right fit for smokers over 35 or those who struggle with daily pill-taking.

Pros

  • Non-invasive, no insertion procedure required

  • Effects can be stopped immediately by discontinuing the pill

  • May help regulate periods and reduce acne for some users

  • Widely available as a low-cost generic

Cons

  • Requires taking a pill at the same time every day

  • Effectiveness depends on consistent daily use

  • Boxed warning for cardiovascular risk in smokers over 35

  • Costs more per month than Kyleena, roughly $30 to $70 versus $20 to $24

Kyleena

Kyleena trades daily upkeep for a single procedure that covers years of contraception with mostly local hormone exposure. It requires a clinician for both placement and removal, which is a bigger commitment upfront.

Pros

  • Provides continuous protection for up to 5 years without daily action

  • Delivers hormone locally, with lower systemic exposure

  • Removes the risk of missed or late doses

  • Cheaper per month over its 5-year lifespan, roughly $20 to $24 versus $30 to $70 for Aviane

Cons

  • Requires a clinician visit for insertion and removal

  • Small risk of uterine perforation or device displacement

  • Insertion may cause cramping or discomfort

  • Not approved for emergency contraception

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