Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 22nd, 2026.
Sildenafil treats erectile dysfunction and pulmonary arterial hypertension
Prescription medication that works by improving blood flow
Requires careful medical supervision and specific usage guidelines
Not suitable for everyone, especially those with certain heart conditions
Sildenafil is a versatile medication primarily known for treating two significant medical conditions: erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Originally developed as a potential heart medication, this drug has transformed how medical professionals approach these specific health challenges. While many people recognize its brand name Viagra, sildenafil exists in multiple formulations designed to address different patient needs.
Modern medical technology has made sildenafil a game-changing treatment option for millions of patients worldwide. Its mechanism of action focuses on relaxing blood vessels and improving circulation, which provides therapeutic benefits for both sexual function and pulmonary health.
Sildenafil works by blocking a specific enzyme called phosphodiesterase type 5 (PDE5), which helps increase blood flow to targeted areas of the body. In erectile dysfunction treatment, this means enhanced blood circulation to the penis, enabling and maintaining an erection. For pulmonary arterial hypertension patients, the increased blood flow helps reduce pressure in the lungs, making breathing easier and improving overall cardiovascular function.
Physicians typically prescribe sildenafil in specific dosages based on individual patient needs. For erectile dysfunction, standard doses range from 25mg to 100mg taken approximately one hour before sexual activity. Patients with high blood pressure should discuss potential interactions with their healthcare provider.
PAH treatment requires different dosing strategies, often involving multiple daily doses to maintain consistent medication levels. Patients might start on lower doses and gradually adjust based on individual response and medical monitoring.
Like many prescription medications, sildenafil can produce side effects. Common experiences include headaches, facial flushing, indigestion, and nasal congestion. More serious but rare side effects might involve sudden vision changes, hearing loss, or prolonged erections.
Individuals with cardiovascular conditions should be particularly cautious. Sildenafil can interact negatively with nitrate medications and can cause dangerous blood pressure fluctuations.
Condition |
Sildenafil Recommendation |
|---|---|
Heart Disease |
Consult physician before use |
Nitrate Medications |
Do not combine |
Liver/Kidney Issues |
Potential dose adjustment needed |
Age Over 65 |
May require lower initial dosage |
Not everyone is an ideal candidate for sildenafil. Patients needing to refill prescriptions should always consult their healthcare provider. Individuals with the following conditions should avoid or use extreme caution:
Severe heart or liver problems
Recent stroke or heart attack
Uncontrolled high blood pressure
Certain eye conditions
Bleeding disorders
Sildenafil is the generic version of the brand-name drug Viagra, containing the same active ingredient.
Typically, the medication becomes effective within 30-60 minutes after consumption.
While primarily prescribed for men, some studies explore potential off-label uses for women with specific medical conditions.
When monitored by a healthcare professional, many patients use sildenafil safely for extended periods.
Yes, sildenafil requires a prescription from a licensed healthcare provider.
Understanding sildenafil involves recognizing its complex medical applications and potential benefits. Always consult medical professionals to determine if this medication suits your specific health needs.
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Sildenafil is a versatile medication primarily known for treating two significant medical conditions: erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). [...]
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