What Drugs Should Not Be Taken With Benzonatate?

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 12th, 2026.

Key Takeaways

  • Benzonatate is a cough suppressant that requires careful consideration when combined with other medications.

  • Certain drugs can interact negatively with Benzonatate, increasing side effects or reducing effectiveness.

  • Understanding these interactions helps prevent complications and ensures safe use of Benzonatate.

  • Consulting a healthcare provider via telehealth services like Doctronic.ai can provide personalized guidance.

Understanding Benzonatate and Its Use

Benzonatate is a prescription medication used to relieve coughs caused by colds, bronchitis, pneumonia, or other respiratory conditions. It works by numbing the throat and lungs, reducing the cough reflex. While effective, Benzonatate must be used carefully, especially when taken alongside other drugs.

Because Benzonatate acts on the nervous system to suppress cough, it can interact with medications that affect the central nervous system or have similar side effects. These interactions could increase risks such as sedation, dizziness, or even more severe complications.

Importance of Sharing Medical History and Current Medications

It is crucial for patients to disclose their complete medical history and any other medications they are currently taking to their healthcare provider before starting Benzonatate. This includes over-the-counter drugs, herbal supplements, and any recreational substances. Such transparency helps to mitigate potential adverse effects and ensures that the treatment plan is tailored to the individual’s needs. Patients should be aware of the importance of adhering to the prescribed dosage, as taking more than recommended can lead to serious side effects, including confusion or hallucinations.

Pediatric Alternatives and Parental Precautions

Benzonatate is typically not recommended for use in children under the age of 10 due to the risk of accidental overdose and severe respiratory distress. Parents should be particularly vigilant and consult with a pediatrician for appropriate cough management strategies for younger patients. In some cases, alternative treatments such as cough suppressants containing dextromethorphan or natural remedies may be suggested, depending on the underlying cause of the cough and the child's overall health status.

Woman wearing a scarf and sweater, coughing and holding her chest against an orange backgroundDrugs That May Interact With Benzonatate

Central Nervous System Depressants

Benzonatate can enhance the sedative effects of central nervous system (CNS) depressants. These include:

  • Alcohol

  • Benzodiazepines (e.g., diazepam, lorazepam)

  • Opioids (e.g., morphine, oxycodone)

  • Barbiturates

  • Some sleep medications

Combining Benzonatate with these drugs may cause excessive drowsiness, respiratory depression, or impaired coordination, increasing the risk of accidents or overdose. It is crucial for patients to be aware of these interactions, especially if they are prescribed multiple medications. Always consult a healthcare provider to ensure safe use, as combining these substances can lead to compounded effects that may not be immediately apparent. Individuals should exercise caution when taking Benzonatate alongside CNS depressants, as it may impair alertness and increase the risk of accidents involving driving or operating heavy machinery.

Other Cough and Cold Medications

Many over-the-counter cough and cold remedies contain ingredients that may interact with Benzonatate. For example, combining multiple cough suppressants can lead to increased side effects such as dizziness or confusion. It is important to avoid taking Benzonatate with other antitussives unless directed by a healthcare provider. Some common ingredients found in these medications include dextromethorphan and guaifenesin, which, when taken with Benzonatate, may enhance the risk of adverse effects. Patients should carefully read labels and consult pharmacists or healthcare professionals to avoid unintentional overdoses or heightened side effects from these combinations.

Medications Affecting Heart Rhythm

Though rare, Benzonatate has been reported to cause heart rhythm disturbances in some cases. Combining it with drugs that affect cardiac conduction, such as certain antiarrhythmics or medications that prolong the QT interval, may increase this risk. Patients with heart conditions should discuss this with their doctor before using Benzonatate. Patients should monitor any unusual symptoms, such as palpitations or changes in heart rate, and promptly report them to their healthcare provider. Awareness of personal and family medical history can also play a significant role in assessing the safety of using Benzonatate in conjunction with other heart-related medications, as certain underlying conditions may heighten the risk of adverse cardiovascular events.

Why Drug Interactions Matter With Benzonatate

Potential Side Effects From Interactions

Drug interactions with Benzonatate can lead to side effects like:

  • Severe dizziness or lightheadedness

  • Confusion or hallucinations

  • Difficulty breathing

  • Excessive sedation or loss of consciousness

These effects can be dangerous, especially if the person is driving, operating machinery, or managing other health conditions. The risk of experiencing these side effects can be exacerbated by factors such as age, pre-existing health conditions, and the overall number of medications a person is taking. Older adults, for instance, may be more susceptible to the sedative effects of Benzonatate, leading to an increased likelihood of falls or accidents. Individuals with respiratory issues may find that interactions with other medications can further compromise their ability to breathe comfortably, making it crucial to monitor any changes in health closely.

Risk of Overdose

Taking Benzonatate with other sedatives or CNS depressants may increase the risk of overdose. Symptoms of overdose include numbness around the mouth, seizures, and cardiac arrest. Immediate medical attention is necessary if an overdose is suspected. It is important to note that the risk of overdose is not solely limited to intentional misuse; even prescribed combinations can lead to dangerous levels of the drug in the system. Patients should always communicate openly with their healthcare providers about all medications they are taking, including over-the-counter drugs and herbal supplements, as these can also interact with Benzonatate. Understanding the signs of overdose can empower patients and their families to act swiftly in emergencies, potentially saving lives.

How to Safely Use Benzonatate With Other Medications

Consult Healthcare Professionals

Before starting Benzonatate, it is essential to inform your healthcare provider about all medications, supplements, and herbal products you are taking. This helps identify potential interactions and adjust treatment accordingly.

Doctronic.ai offers quick access to medical advice from licensed professionals. They can review your medication list and provide personalized recommendations without the need to visit a clinic in person.

Read Medication Labels Carefully

Always read the labels of over-the-counter products to avoid duplicating cough suppressants or other active ingredients that might interact with Benzonatate. If unsure, ask a pharmacist or healthcare provider for guidance.

Monitor for Side Effects

Pay attention to how your body reacts when starting Benzonatate, especially if you are on other medications. Report any unusual symptoms such as severe drowsiness, confusion, or breathing difficulties immediately.

When to Seek Medical Help

If you experience symptoms like difficulty breathing, severe dizziness, confusion, or signs of an allergic reaction while taking Benzonatate, seek emergency medical care. These could indicate serious drug interactions or adverse effects.

For non-emergency concerns or questions about medication interactions, Doctronic.ai provides a convenient way to get expert advice quickly and safely from home.

Frequently Asked Questions

It is not recommended to drink alcohol while using Benzonatate because both can depress the central nervous system, increasing the risk of severe drowsiness and breathing problems.

Some painkillers, especially opioids, can interact with Benzonatate and increase sedation or respiratory depression. Always consult your healthcare provider before combining these medications.

If you accidentally take Benzonatate with another cough suppressant, monitor yourself for increased side effects such as dizziness or confusion. Contact your healthcare provider or use a telehealth service like Doctronic.ai for advice.

Consult your doctor or pharmacist, or use trusted telehealth services such as Doctronic.ai to review your medications and identify potential interactions.

Many medications do not interact with Benzonatate, but it is important to discuss all your medications with a healthcare professional to ensure safety.

References

The Bottom Line

Benzonatate can be an effective cough suppressant, but combining it with certain medications, especially CNS depressants or other cough remedies, can be dangerous. Understanding potential drug interactions and monitoring side effects is essential for safe use. For personalized guidance and quick medication reviews, consult licensed healthcare professionals through Doctronic.ai for convenient, reliable telehealth support.

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