4 Stendra Interactions: What To Avoid When You’re Taking Stendra

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 19th, 2025.

Key Takeaways

  • Stendra (avanafil) is a medication used to treat erectile dysfunction and can interact with several drugs and substances.
  • Combining Stendra with nitrates or certain blood pressure medications can cause dangerous drops in blood pressure.
  • Alcohol and Stendra together may increase side effects like dizziness and lower blood pressure.
  • Some supplements and over-the-counter medications can affect how Stendra works or increase risks.
  • Understanding these interactions helps ensure safe and effective use of Stendra.
  • Telehealth services like Doctronic.ai can provide personalized advice based on your health history.
  • If you experience unusual symptoms or have questions about Stendra interactions, consult a healthcare provider promptly.

Understanding Stendra Interactions for Safe Usage

Stendra, known generically as avanafil, is part of a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors, which work by increasing blood flow to the penis during sexual stimulation. This mechanism is crucial for achieving and maintaining an erection, making it an effective treatment for men experiencing erectile dysfunction. However, it is essential to note that Stendra does not automatically cause an erection; sexual arousal is still necessary for the medication to take effect. Understanding how Stendra interacts with various substances can empower patients to make informed decisions about their health and well-being.

In addition to the potential interactions with prescription medications, individuals should also be cautious about herbal supplements and natural remedies that claim to enhance sexual performance. Some of these products may contain ingredients that could either diminish the effectiveness of Stendra or lead to unexpected side effects. For instance, supplements like ginseng or yohimbine can have their own set of interactions and side effects. Therefore, it is advisable to discuss any supplements with a healthcare provider before starting them, especially if you are considering using Stendra as part of your treatment plan.

Knowing what to avoid while taking Stendra is crucial. Some interactions can lead to serious health issues like dangerously low blood pressure, while others may reduce the medication’s effectiveness. This guide covers seven key interactions to watch for, helping you use Stendra safely and confidently.

1. Stendra and Nitrates

Nitrates are medications commonly prescribed for chest pain or heart conditions, such as nitroglycerin or isosorbide dinitrate. Combining Stendra with nitrates is strongly contraindicated.

Both drugs cause blood vessels to dilate, which can lead to a significant and potentially life-threatening drop in blood pressure. Symptoms may include dizziness, fainting, or even a heart attack in severe cases. Avoid using Stendra if you are currently taking any nitrate medications.

2. Stendra and Alpha-Blockers

Alpha-blockers like tamsulosin or doxazosin are used to treat high blood pressure and prostate issues. When taken with Stendra, they can also cause blood pressure to fall too low.

While some patients may use both under close medical supervision, it’s essential to start with the lowest doses and monitor symptoms carefully. Signs of interaction include lightheadedness, headache, or palpitations.

3. Stendra and Other Erectile Dysfunction Medications

Using Stendra alongside other PDE5 inhibitors like sildenafil (Viagra) or tadalafil (Cialis) is not recommended. Combining these medications increases the risk of side effects such as severe headaches, flushing, or low blood pressure.

Always inform your healthcare provider about any ED medications you are currently taking before starting Stendra.

4. Stendra and Blood Pressure Medications

Many blood pressure medications, including beta-blockers and calcium channel blockers, can interact with Stendra. The combined effect may cause blood pressure to drop too low, leading to dizziness or fainting.

Discuss all your medications with your doctor to adjust dosages if necessary. Never stop or change blood pressure medications without medical advice.

A doctor handing a patient a blister pack of pills across a desk with medical forms and medication bottlesStendra Interactions With Supplements and OTC Medications

Common Supplements That May Interact

Some over-the-counter supplements, especially those aimed at boosting sexual performance or containing nitrates (like certain “natural” heart health supplements), can interact dangerously with Stendra. Herbal supplements such as ginseng or yohimbine may also increase side effects like rapid heartbeat or high blood pressure.

OTC Medications to Watch For

Medications like decongestants or antihistamines may affect blood pressure or heart rate, potentially interacting with Stendra. Always check with a healthcare provider before combining any OTC drugs with Stendra.

Stendra and Alcohol

Drinking alcohol while taking Stendra can increase the risk of side effects such as dizziness, headache, and low blood pressure. Alcohol itself can impair erectile function, potentially reducing the effectiveness of Stendra.

Limit alcohol intake when using Stendra to avoid these complications. If you experience symptoms like fainting or severe dizziness, seek medical help immediately.

Stendra and Food Interactions

While Stendra can be taken with or without food, a high-fat meal may delay its absorption, making it take longer to work. This doesn’t reduce the overall effectiveness but can affect timing.

For best results, consider taking Stendra on an empty stomach or after a light meal. Avoid grapefruit or grapefruit juice, as it can interfere with how your body processes the medication.

Avoiding Stendra Interactions

The best way to avoid dangerous interactions is to keep your healthcare provider informed about all medications, supplements, and substances you use. This includes prescription drugs, over-the-counter medications, vitamins, and herbal products.

Using telehealth services like Doctronic.ai can help you get personalized advice quickly. Doctronic’s AI-powered platform considers your medical history and current medications to provide tailored guidance on Stendra interactions and safe usage.

When to Contact Your Doctor About Stendra Interactions

Seek immediate medical attention if you experience any of the following after taking Stendra:

  • Severe dizziness or fainting

  • Chest pain or irregular heartbeat

  • Sudden vision loss or changes

  • Prolonged erection lasting more than 4 hours (priapism)

If you have questions about how Stendra interacts with your medications or supplements, reach out to a healthcare professional. Telehealth platforms like Doctronic.ai offer convenient access to doctors who can answer your questions anytime, anywhere.

The Bottom Line About Stendra Interactions

Stendra is a powerful medication that can improve the quality of life for many men. However, its safety depends on understanding and avoiding interactions with other drugs, supplements, and alcohol. Always communicate openly with your healthcare provider about all substances you are taking.

For quick, personalized advice, consider using Doctronic.ai. Their AI-driven platform offers 24/7 access to expert medical guidance tailored to your unique health profile, helping you navigate medication interactions with confidence.

Frequently Asked Questions

It depends on the type of blood pressure medication. Some, like alpha-blockers, require caution due to the risk of low blood pressure. Always consult your doctor before combining these medications.

Moderate alcohol consumption may be safe for some, but it can increase side effects like dizziness and reduce the effectiveness of Stendra. Limiting alcohol is recommended.

This combination can cause a dangerous drop in blood pressure. Seek emergency medical help immediately if this happens.

Some herbal supplements can interact with Stendra and cause side effects. Always discuss any supplements with your healthcare provider before use.

Doctronic.ai uses advanced AI to provide personalized medical advice, considering your full medical history and current medications. This helps you avoid dangerous interactions and use Stendra safely.

References

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