Exploring Therapies for Managing Diabetic Neuropathy
Published: May 05, 2024
Diabetic neuropathy can be challenging to manage, but various therapies offer hope for relief.
Contents
Medication Options
First-line medications include antidepressants and gabapentinoids. These drugs help manage pain by altering neurotransmitter activity and calming nerve signals. Each patientβs therapy should be tailored to their specific needs, considering factors like side effects and cost.
Topical and Nonpharmacologic Therapies
For those preferring nonpharmacologic treatments, capsaicin cream and lidocaine patches provide localized relief. Other options include alpha-lipoic acid supplements and therapies like acupuncture and spinal cord stimulation, which have shown promise in reducing symptoms.

Why Avoid Opioids
Opioids are generally not recommended due to risks of addiction and limited long-term effectiveness. Safer alternatives exist, making them a last-resort option under professional guidance.
Frequently Asked Questions
Antidepressants and gabapentinoids are common choices.
Yes, capsaicin cream and acupuncture can help.
Opioids are not recommended due to addiction risks.
Alpha-lipoic acid supplements may reduce symptoms.
Finding Relief
There are many therapy options for managing diabetic neuropathy; finding the right one can make a big difference.
References
- Griebeler ML, Morey-Vargas OL, Brito JP, et al. Pharmacologic interventions for painful diabetic neuropathy: An umbrella systematic review and comparative effectiveness network meta-analysis. Ann Intern Med 2014; 161:639.
- Price R, Smith D, Franklin G, et al. Oral and Topical Treatment of Painful Diabetic Polyneuropathy: Practice Guideline Update Summary: Report of the AAN Guideline Subcommittee. Neurology 2022; 98:31.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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