When Do Zepbound Side Effects Start

Zepbound side effects typically begin within the first few days of treatment. Most patients experience initial side effects like nausea, vomiting, or diarrhea within 1-3 days of their first injection. These gastrointestinal symptoms are most common during the first 4-8 weeks as your body adjusts to the medication. Clinical trials show that 84% of patients experience some side effects, with nausea being the most frequent at 29%. Side effects often peak during dose escalations, which occur every 4 weeks. Many symptoms gradually improve after 8-12 weeks of consistent treatment. Injection site reactions may appear immediately after administration, while systemic effects develop over several days.

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