Medication Guides

What Are the Side Effects of Lipitor?

Andre Stone | MD

Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.

Possible Lipitor side effects include muscle pain, headache, and digestive problems, but their likelihood varies by symptom, dose, and study. Most side effects are mild, including nausea, diarrhea, constipation, and fatigue. Muscle-related problems range from minor aches to rhabdomyolysis, a rare but serious breakdown of muscle tissue that can damage the kidneys. Other potential effects include elevated liver enzymes and increased blood sugar. Rare reports of memory problems or confusion have also occurred and were generally reversible. Liver tests are usually checked before treatment and later when clinically indicated. Serious side effects like severe muscle damage or liver problems require immediate medical attention. Contact your doctor if you experience unexplained muscle pain, weakness, or dark-colored urine while taking Lipitor.

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