Does Amlodipine Cause Weight Gain?

Amlodipine typically does not cause significant weight gain as a direct side effect. Clinical studies show that fluid retention affects less than 3% of patients taking amlodipine, and any weight changes are usually minimal. The medication works by relaxing blood vessels rather than affecting metabolism or appetite directly. However, some patients may experience mild swelling in the ankles or feet due to increased fluid retention, which could contribute to a slight increase on the scale. If you notice unexplained weight gain of more than 2-3 pounds while taking amlodipine, consult your healthcare provider to rule out other causes or adjust your treatment plan.