How Many Excedrin Migraine Can You Take in 24 Hours?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
The maximum safe dose of Excedrin Migraine is 2 tablets in 24 hours. Each tablet contains 250mg acetaminophen, 250mg aspirin, and 65mg caffeine, totaling 1,000mg acetaminophen and 500mg aspirin per day when taking the maximum dose. You should not exceed this limit as it approaches the daily maximum for acetaminophen (3,000-4,000mg). Take tablets at least 4 hours apart and avoid other acetaminophen-containing medications. Never take more than 10 days per month to prevent rebound headaches.
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