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Vitamin B2 for Migraine Prevention
March 31st, 2026

Does Riboflavin Prevent Migraines?

Yes, riboflavin (vitamin B2) can help prevent migraines in some people. Clinical studies show that taking 400mg of riboflavin daily reduces migraine frequency by approximately 50% after 3-4 months of consistent use. The vitamin works by improving mitochondrial energy production in brain cells, which may help prevent the cellular dysfunction that triggers migraines. Research indicates riboflavin is most effective for people who have frequent migraines (4 or more per month) and appears to work better as a preventive measure rather than treating active headaches. Side effects are minimal, though high doses may cause bright yellow urine, which is harmless.

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