Does Paroxetine Cause More Weight Gain than Other Ssris?

Yes, paroxetine (Paxil) causes more weight gain than most other SSRIs. Studies show paroxetine users gain an average of 3-5 pounds over 6-12 months, compared to 1-3 pounds with sertraline or fluoxetine. This occurs because paroxetine has stronger antihistamine and anticholinergic effects that slow metabolism and increase appetite. Long-term studies indicate up to 25% of paroxetine users experience clinically significant weight gain (>7% of body weight), versus 10-15% with other SSRIs. Escitalopram and sertraline are generally considered more weight-neutral alternatives. If weight gain is a concern, discuss switching medications with your doctor.