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Brenzavvy (bexagliflozin) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works by blocking the SGLT2 protein in the kidneys, which normally reabsorbs glucose back into the blood. By inhibiting this protein, Brenzavvy causes excess glucose to be removed from the body through urine, lowering blood sugar levels in adults with type 2 diabetes.

Brenzavvy is approved by the FDA for adults with type 2 diabetes as an adjunct to diet and exercise to improve glycemic control. It is not approved for type 1 diabetes and should not be used in patients with severely reduced kidney function or those on dialysis.

The most commonly reported side effects include urinary tract infections, genital yeast infections, and increased urination. More serious but less common risks include diabetic ketoacidosis, acute kidney injury, low blood pressure, and a rare genital infection called necrotizing fasciitis. Your doctor will review your individual risk factors before prescribing.

Brenzavvy can be used alone or in combination with other antidiabetic agents such as metformin, insulin, or DPP-4 inhibitors, depending on your treatment plan. Your physician will evaluate your current medications to check for interactions and determine the safest and most effective combination for you.

On its own, Brenzavvy has a low risk of causing hypoglycemia. However, the risk increases when it is combined with insulin or insulin secretagogues such as sulfonylureas. Your physician may recommend adjusting the doses of those medications when starting Brenzavvy.

Brenzavvy is taken orally once daily, with or without food. It is typically taken in the morning. Follow your prescribing physician's instructions carefully, and do not adjust your dose without consulting them. Regular monitoring of your blood sugar and kidney function is recommended while on this medication.

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