What Increases Your Risk When Taking NSAIDs?
Published: Nov 25, 2023
NSAIDs are popular for treating pain and inflammation, but certain factors can increase the risk of experiencing serious side effects.
Contents
Dose Matters
The risk of side effects from NSAIDs increases with higher doses. Even medications considered safe, like ibuprofen, can become risky if taken in large amounts. It's crucial to follow the prescribed doses and consult a healthcare provider if you're unsure.
Drug Interactions
NSAIDs can interact with other medications, leading to increased side effects. For example, taking ibuprofen with aspirin may reduce the effectiveness of aspirin's heart-protective effects. Always inform your doctor about all the medications you're taking.

Comorbid Conditions
Individuals with pre-existing conditions like heart disease, kidney issues, or gastrointestinal problems are at higher risk when using NSAIDs. These conditions can exacerbate side effects, making it essential to manage them carefully with professional guidance.
Frequently Asked Questions
Higher doses increase the risk of side effects.
Yes, they can interact and increase side effects.
People with heart, kidney, or stomach issues.
Ibuprofen may reduce aspirin's heart benefits.
Key Takeaways
Understanding your risk factors can help you use NSAIDs safely and effectively.
References
- Howard RL, Avery AJ, Slavenburg S, et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol 2007; 63:136.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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