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Antithrombotic Therapy: A Lifesaver After Stroke?
Published: Oct 22, 2023
Antithrombotic therapy plays a crucial role in preventing future strokes in patients who've experienced an ischemic stroke or transient ischemic attack (TIA).
Antiplatelet Agents for Stroke Prevention
For individuals with noncardioembolic ischemic stroke or TIA, antiplatelet agents are a key therapy option. Aspirin, clopidogrel, and aspirin-extended-release dipyridamole are commonly used to prevent recurrence. These medications work by preventing platelets from sticking together, thereby reducing the risk of clot formation. Overall, they are effective for long-term management and play a significant role in reducing subsequent stroke incidents.
Dual Antiplatelet Therapy (DAPT) Explained
Dual antiplatelet therapy, often involving aspirin plus clopidogrel, is recommended for certain high-risk patients. This approach is beneficial for those with a recent minor ischemic stroke or TIA and can also help patients with symptomatic intracranial atherosclerosis. DAPT is typically used in the short term to maximize the prevention of clot formation during a critical period. However, it is crucial to balance the benefits against the risk of increased bleeding.
Anticoagulation for Cardiogenic Embolism
For patients with strokes caused by cardiogenic embolism, long-term anticoagulation is often necessary. This includes medications like warfarin and direct oral anticoagulants such as dabigatran and apixaban. These drugs help prevent future strokes by reducing blood clot formation in patients with conditions like atrial fibrillation. Although there's a risk of major bleeding, for many patients, the benefits of preventing strokes outweigh the risks.
Frequently Asked Questions
It's a treatment to prevent blood clots, reducing stroke risk.
Aspirin is effective but sometimes combined with other drugs for better results.
Patients with strokes from heart-related issues like atrial fibrillation.
Yes, there's an increased bleeding risk, so it's carefully prescribed.
Wrapping Up
Antithrombotic therapy is crucial in stroke prevention but must be tailored individually.
References
- Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke 2021; 52:e364.
- Amarenco P, Kim JS, Labreuche J, et al. A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke. N Engl J Med 2020; 382:9.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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