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Why Does My Stomach Hurt After Taking Antibiotics?
Understanding Antibiotic Side Effects
March 31st, 2026
Why Does My Stomach Hurt After Taking Antibiotics?
Antibiotics commonly cause stomach pain because they disrupt the balance of beneficial bacteria in your digestive tract. These medications kill harmful bacteria causing your infection, but they also eliminate up to 90% of the healthy gut microbiome that aids digestion and protects your intestinal lining. This disruption can lead to inflammation, increased stomach acid production, and digestive upset. Common symptoms include cramping, nausea, and diarrhea, which affect approximately 25% of antibiotic users. Taking antibiotics with food, consuming probiotics, and staying hydrated can help minimize these effects. Most stomach discomfort resolves within a few days after completing your antibiotic course as your gut bacteria gradually restore themselves.
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