When Should You Take Bupropion?

Bupropion should typically be taken in the morning to avoid sleep disruption. The immediate-release formulation is usually prescribed twice daily (morning and mid-afternoon), while extended-release versions are taken once daily in the morning. Taking bupropion with food can help reduce stomach upset, though it's not strictly necessary. Most patients start seeing antidepressant effects within 1-2 weeks, with full benefits emerging after 4-6 weeks of consistent use. The timing remains consistent regardless of whether you're using it for depression, smoking cessation, or weight management, as all applications benefit from morning dosing to prevent insomnia.