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Comparing ED Medication Options
March 31st, 2026

What is the Difference Between Sildenafil and Tadalafil?

Sildenafil and tadalafil are both PDE5 inhibitors that treat erectile dysfunction, but they differ significantly in duration and timing. Sildenafil (Viagra) typically lasts 4-6 hours and should be taken 30-60 minutes before sexual activity. Tadalafil (Cialis) can remain effective for up to 36 hours, earning it the nickname "the weekend pill." Both medications have similar effectiveness rates of 60-70% in clinical trials. Tadalafil also comes in a daily low-dose option (2.5-5mg) for continuous treatment, while sildenafil is primarily taken as needed. Side effects are comparable, though tadalafil may cause fewer visual disturbances. The choice between them often depends on lifestyle preferences and individual response patterns.

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