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Common Causes of Upper Abdominal Pain
March 31st, 2026

What Causes Stomach Pain Above the Belly Button?

Stomach pain above the belly button typically stems from gastritis, peptic ulcers, or gastroesophageal reflux disease (GERD). The epigastric region houses the stomach and duodenum, making these organs common culprits when upper abdominal discomfort occurs. Gastritis affects up to 20% of adults annually and causes inflammation of the stomach lining from factors like H. pylori bacteria, NSAIDs, or excessive alcohol consumption. Peptic ulcers, found in 10% of people worldwide, create burning sensations that worsen with empty stomach conditions. GERD impacts 20% of Americans and causes acid to back up into the esophagus. Other causes include gallbladder disease, pancreatitis, or muscle strain from physical activity.

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