What Causes Restless Legs at Night?

Restless legs syndrome at night stems from disrupted dopamine signaling in the brain's movement control centers. Iron deficiency affects up to 25% of cases, as iron helps produce dopamine neurotransmitters essential for muscle control. Other common triggers include pregnancy (affecting 10-34% of expectant mothers), kidney disease, diabetes, and certain medications like antihistamines or antidepressants. The condition worsens during evening hours because dopamine levels naturally decline as part of your circadian rhythm. Genetics play a significant role, with 40-90% of cases running in families. Caffeine, alcohol, and sedentary behavior can intensify symptoms by further disrupting neurotransmitter balance.