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Step-by-Step Injection Guide
February 19th, 2026

How to Inject Zepbound

Zepbound injections are administered subcutaneously once weekly using the provided prefilled pen. Choose an injection site on your thigh, abdomen, or upper arm, rotating locations each week to prevent tissue irritation. Remove the pen cap, select your prescribed dose, and insert the needle at a 90-degree angle into pinched skin. Press and hold the injection button until you hear two clicks, then hold for 10 additional seconds before removing. The FDA-approved dosing schedule starts at 2.5mg weekly, escalating to 5mg, 7.5mg, 10mg, and up to 15mg based on tolerance and weight loss response over 16-20 weeks.

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