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STDs & Sexual Health

How Long Does Syphilis Take to Show Symptoms?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 22nd, 2026.

Syphilis symptoms typically appear 10-90 days after exposure, with most people developing the first signs within 3 weeks. The initial symptom is usually a painless sore called a chancre that appears at the infection site. This primary stage lasts 3-6 weeks before the sore heals on its own, even without treatment. However, the infection remains active and progresses to secondary syphilis if untreated. Secondary symptoms like rashes, fever, and swollen lymph nodes can develop 2-8 weeks after the chancre disappears. Some people may not notice the initial sore, especially if it's in a hidden location, making early detection challenging.

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