How Long Does It Take for Amoxicillin to Work for a Tooth Infection?
Medically reviewed by Lauren Okafor | MD, The Frank H Netter MD School of Medicine, Loyola University Medical Center on August 22nd, 2026.
Amoxicillin typically begins reducing tooth infection symptoms within 24-48 hours of starting treatment. Most patients notice decreased pain and swelling by the second or third day, though the antibiotic continues working throughout the full course. Complete resolution of infection usually occurs within 7-10 days when taking the prescribed 500mg dose three times daily. However, it's crucial to finish the entire prescribed course, even if symptoms improve earlier, to prevent antibiotic resistance and ensure complete bacterial elimination. If pain and swelling don't improve within 48-72 hours, contact your dentist immediately as you may need a different antibiotic or additional dental intervention.
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