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How Long Does Amoxicillin Stay in Your System?
Understanding Antibiotic Elimination Times
March 31st, 2026
How Long Does Amoxicillin Stay in Your System?
Amoxicillin typically clears from your system within 24-48 hours after your last dose. The antibiotic has a half-life of approximately 1-1.3 hours, meaning your body eliminates half of the drug from your bloodstream every hour. Most people will have undetectable levels within 8-12 hours, though trace amounts may remain for up to 2 days. Your kidneys process about 60% of amoxicillin unchanged through urine, while the liver metabolizes the remainder. Factors like kidney function, age, and overall health can affect elimination time. People with kidney problems may retain the medication longer, requiring dosage adjustments from their healthcare provider.
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