Does Testosterone Replacement Therapy Cause Acne?

Yes, testosterone replacement therapy can cause acne as a common side effect. When testosterone levels increase, sebaceous glands produce more oil, which can clog pores and lead to breakouts. Studies show that 15-25% of men on TRT experience some degree of acne, particularly during the first 3-6 months of treatment. The acne typically appears on the face, chest, shoulders, and back. Most cases are mild to moderate and can be managed with proper skincare routines, topical treatments, or adjusting the testosterone dosage. Severe acne may require dermatological intervention or treatment modifications.