Does Prednisone Affect Your Immune System?

Yes, prednisone significantly suppresses your immune system by reducing inflammation and white blood cell activity. This corticosteroid works by mimicking cortisol, a hormone that naturally regulates immune responses. Prednisone decreases the production and function of T-cells, B-cells, and other immune cells that fight infections. Studies show that doses above 20mg daily can increase infection risk by up to 40%. While this immunosuppression helps treat conditions like asthma, arthritis, and allergic reactions, it also makes you more vulnerable to bacterial, viral, and fungal infections. The higher your dose and longer your treatment duration, the greater the immune suppression becomes.