Does Metformin Cause Diarrhea?
Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.
Yes, metformin commonly causes diarrhea as a gastrointestinal side effect. Diarrhea is one of metformin’s most common side effects, although estimates vary among studies. The exact cause is not fully understood, but metformin’s effects in the intestines may contribute. The diarrhea typically develops within the first few weeks of treatment and often improves as your body adjusts to the medication. Taking metformin with food may help. A clinician may also recommend adjusting the dose or switching to an extended-release form. Symptoms often improve as the body adjusts, but contact a clinician if diarrhea is severe, causes signs of dehydration, or does not improve. Do not change or stop metformin without medical guidance.
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