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Does Metformin Cause Diarrhea?
Common Metformin Side Effects
March 31st, 2026
Does Metformin Cause Diarrhea?
Yes, metformin commonly causes diarrhea as a gastrointestinal side effect. Studies show that up to 53% of patients experience diarrhea when starting metformin, making it one of the most frequent adverse reactions. This occurs because metformin affects glucose absorption in the intestines and alters gut bacteria composition. The diarrhea typically develops within the first few weeks of treatment and often improves as your body adjusts to the medication. Taking metformin with food, starting with a lower dose, or switching to extended-release formulations can help reduce this side effect. Most patients find the diarrhea becomes manageable or resolves completely within 2-4 weeks of consistent use.
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