Does Caffeine Interact with Any Medications?

Yes, caffeine can interact with some medications, potentially changing their effects or increasing side effects. Caffeine interferes with how your liver processes certain drugs, particularly affecting medications metabolized by the CYP1A2 enzyme system. Some medicines may interact with caffeine. For example, ciprofloxacin can slow caffeine clearance and increase caffeine-related side effects. Evidence for a clinically important interaction between usual caffeine intake and warfarin is limited, but large changes in caffeine intake should be discussed with a clinician. Certain psychiatric medicines, heart medicines, and bronchodilators may also interact with caffeine, depending on the specific drug and the amount of caffeine consumed. The importance of an interaction depends on the specific medicine, the amount and timing of caffeine, and individual factors. Ask a pharmacist or prescribing clinician whether you need to limit caffeine, and do not change a prescribed medicine on your own.