Can You Take Melatonin with Lexapro?
Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.
Yes, melatonin can generally be taken with Lexapro (escitalopram) as there are no major drug interactions between these medications. Melatonin and Lexapro work differently, and no major direct interaction is known. However, taking them together may increase drowsiness. There is no well-established evidence that typical melatonin doses reduce the effectiveness of Lexapro, but research on this specific combination is limited. However, combining them may increase drowsiness since both can cause sedation. Some patients report improved sleep quality when using melatonin alongside their antidepressant. Always consult your prescribing physician before adding melatonin to your medication regimen, especially if you experience unusual side effects or take other medications.
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