Can You Take Melatonin with Benadryl?
Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.
Taking melatonin with Benadryl is generally not recommended due to increased sedation risks. Both medications cause drowsiness and can compound each other's effects, potentially leading to excessive sleepiness, confusion, or difficulty waking up. Combining a sedating antihistamine such as Benadryl with melatonin may increase next-day drowsiness and impairment. Elderly adults face higher risks of falls and cognitive issues when combining these medications. If you're struggling with sleep, consider using one medication at a time and consulting your healthcare provider about safer alternatives. They can help determine the most appropriate sleep aid for your specific situation and medical history.
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